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Publications of INSERM UMR 1125 Physiopathology, targets and therapies of rheumatoid arthritis

Main publications

Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression. Perez J, Dansou B, Hervé R, Levi C, Tamouza H, Vandermeersch S, Demey-Thomas E, Haymann JP, Zafrani L, Klatzmann D, Boissier MC, Letavernier E, Baud L. J Immunol. 2015 Nov 25.

Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis. Semerano L, Duvallet E, Belmellat N, Marival N, Schall N, Monteil M, Grouard-Vogel G, Bernier E, Lecouvey M, Hlawaty H, Muller S, Boissier MC, Assier E. Angiogenesis. 2015 Sep 29.

Cachexia and adiposity in rheumatoid arthritis. Relevance for disease management and clinical outcomes. Challal S, Minichiello E, Boissier MC, Semerano L. Joint Bone Spine. 2015 Jul 13.

Metabolomics for rheumatic diseases: has the time come? Semerano L, Roméo PH, Boissier MC. Ann Rheum Dis. 2015 Jul;74(7):1325-6

Durez P, Vandepapeliere P, Miranda P, Toncheva A, Berman A, Kehler T, Mociran E, Fautrel B, Mariette X, Dhellin O, Fanget B, Ouary S, Grouard-Vogel G, Boissier MC. Therapeutic vaccination with TNF-Kinoid in TNF antagonist-resistant rheumatoid arthritis: a phase II randomized, controlled clinical trial. PLoS One. 2014 Dec 17;9(12):e113465.

Semerano L, Roméo PH, Boissier MC. Metabolomics for rheumatic diseases: has the time come? Ann Rheum Dis. 2015 Jul;74(7):1325-6

Thiolat A, Semerano L, Pers YM, Biton J, Lemeiter D, Portales P, Quentin J, Jorgensen C, Decker P, Boissier MC, Louis-Plence P, Bessis N.Interleukin-6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis. Arthritis Rheumatol. 2014 Feb;66(2):273-83. 

Lindau D, Mussard J, Rabsteyn A, Ribon M, Kötter I, Igney A, Adema GJ, Boissier MC, Rammensee HG, Decker P.TLR9 independent interferon α production by neutrophils on NETosis in response to circulating chromatin, a key lupus autoantigen. Ann Rheum Dis. 2013 Sep 7. doi: 10.1136/annrheumdis-2012-203041.

Lindau D, Mussard J, Wagner BJ, Ribon M,Rönnefarth VM, Quettier M, Jelcic I, Boissier MC, Rammensee HG, Decker P.Primary blood neutrophils express a functional cell surface Toll-like receptor 9. Eur J Immunol. 2013 Aug;43(8):2101-13.

Semerano L, Biton J, Delavallée L, Duvallet E, Assier E, Bessis N, Bernier E, Dhellin O, Grouard-Vogel G, Boissier MC  Protection from articular damage by passive or active anti-tumour necrosis factor (TNF)-α immunotherapy in human TNF-α transgenic mice depends on anti-TNF-α antibody levels. Clin Exp Immunol. 2013 Apr;172(1):54-62. doi: 10.1111/cei.12040

Derré-Bobillot A, Cortes-Perez NG, Yamamoto Y, Kharrat P, Couvé E, Da Cunha V, Decker P, Boissier MC, Escartin F, Cesselin B, Langella P, Bermúdez-Humarán LG, Gaudu P. Nuclease A (Gbs0661), an extracellular nuclease of Streptococcus agalactiae, attacks the neutrophil extracellular traps and is needed for full virulence. Mol Microbiol. 2013 Aug;89(3):518-31. 

Singh-Jasuja H*, Thiolat A*, Ribon M, Boissier MC, Bessis N, Rammensee HG, Decker P. The mouse dendritic cell marker CD11c is down-regulated upon cell activation through Toll-like receptor triggering. Immunobiology. 2013 Jan;218(1):28-39.* equal contribution

Benchmarking biomedical publications worldwide. Boissier MC. Rheumatology (Oxford). 2013 May 10.

Saidenberg-Kermanac'h N, Semerano L, Naccache JM, Brauner M, Falgarone G, Dumont-Fischer D, Guillot X, Valeyre D, Boissier MC. Screening for latent tuberculosis in anti-TNF-α candidate patients in a high tuberculosis incidence setting. Int J Tuberc Lung Dis. 2012 Oct;16(10):1307-14.

Biton J, Boissier MC, Bessis N. TNFα: activator or inhibitor of regulatory T cells? Joint Bone Spine. 2012 Mar;79(2):119-23.

Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac'h N, Falgarone G. Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction. J Autoimmun. 2012 Sep;39(3):222-8.

Assier E, Semerano L, Duvallet E, Delavallée L, Bernier E, Laborie M, Grouard-Vogel G, Larcier P, Bessis N, Boissier MC. Modulation of anti-tumor necrosis factor alpha (TNF-α) antibody secretion in mice immunized with TNF-α kinoid. Clin Vaccine Immunol. 2012 May;19(5):699-703.

Semerano L, Assier E, Boissier MC. Anti-cytokine vaccination: a new biotherapy of autoimmunity? Autoimmun Rev. 2012 Sep;11(11):785.

Rullé S, Ah Kioon MD, Asensio C, Mussard J, Ea HK, Boissier MC, Lioté F, Falgarone G. Adrenomedullin, a neuropeptide with immunoregulatory properties induces semi-mature tolerogenic dendritic cells. Immunology. 2012 Jun;136(2):252-64


Ratsimandresy RA, Duvallet E, Assier E, Semerano L, Delavallée L, Bessis N, Zagury JF, Boissier MC Active immunization against IL-23p19 improves experimental arthritis. Vaccine. 2011 Nov 21;29(50):9329-36

Biton J, Semerano L, Delavallée L, Lemeiter D, Laborie M, Grouard-Vogel G, Boissier MC, Bessis N. Interplay between TNF and regulatory T cells in a TNF-driven murine model of arthritis. J Immunol. 2011 Apr 1;186:3899-910.

Semerano L, Assier E, Delavallée L, Boissier MC. Kinoid of human tumor necrosis factor-alpha for rheumatoid arthritis. Expert Opin Biol Ther. 2011 Apr;11(4):545-50. Mar 9.

Decker P. Neutrophils and interferon-a-producing cells: who produces interferon in lupus? Arthritis Res Ther, 2011, 13:118-20.

Veenbergen S, Bennink MB, Affandi AJ, Bessis N, Biton J, Arntz OJ, van den Berg WB, van de Loo FA. A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis.  Ann Rheum Dis. 2011 Dec;70(12):2167-75.

Duvallet E, Semerano L, Assier E, Falgarone G, Boissier MC. Interleukin-23: A key cytokine in inflammatory diseases. Ann Med. Ann Med. 2011 Nov;43(7):503-11.

Boissier MC. Cell and cytokine imbalances in rheumatoid synovitis. Joint Bone Spine. 2011 ;78:230-4.

Assier E, Boissier MC, Dayer JM. Interleukin-6: from identification of the cytokine to development of targeted treatments. Joint Bone Spine. 2010 ;77:532-6.

Semerano L, Clavel G, Assier E, Denys A, Boissier MC. Blood vessels, a potential therapeutic target in rheumatoid arthritis? Joint Bone Spine. 2011;78:118-23.

Denys A, Thiolat A, Descamps D, Lemeiter D, Benihoud K, Bessis N, Boissier MC.Intra-articular electrotransfer of mouse soluble tumour necrosis factor receptor in a murine model of rheumatoid arthritis. J Gene Med. 2010;12:659-68.

Miellot-Gafsou A, Biton J, Bourgeois E, Herbelin A, Boissier MC, Bessis N. Early activation of invariant natural killer T cells in a rheumatoid arthritis model and application to disease treatment. Immunology. 2010 ;130:296-306.

Delavallée L, Semerano L, Assier E, Vogel G, Vuagniaux G, Laborie M, Zagury D, Bessis N, Boissier MC. Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis. Arthritis Res Ther. 2009;11(6):R195. Epub 2009 Dec 23.

Boissier MC, Assier E, Biton J, Denys A, Falgarone G, Bessis N. Regulatory T cells (Treg) in rheumatoid arthritis. Joint Bone Spine. 2009;76:10-4.

Jaen O, Petit-Teixeira E, Kirsten H, Ahnert P, Semerano L, Pierlot C, Cornelis F, Boissier MC, Falgarone G; European Consortium on Rheumatoid Arthritis Families.No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis. Arthritis Res Ther. 2009;11:R5. Epub 2009 Jan 13.

Jaen O, Rullé S, Bessis N, Zago A, Boissier MC, Falgarone G. Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo. Immunology. 2009;126:35-44..

Launois R, Payet S, Saidenberg-Kermanac'h N, Francesconi C, França LR, Boissier MC. Budget impact model of rituximab after failure of one or more TNFalpha inhibitor therapies in the treatment of rheumatoid arthritis.Joint Bone Spine. 2008;75:688-95.

Boissier MC, Assier E, Falgarone G, Bessis N Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm. Joint Bone Spine. 2008;75:373-5.

Clavel G, Marchiol-Fournigault C, Renault G, Boissier MC, Fradelizi D, BessisN. Ultrasound and Doppler micro-imaging in a model of rheumatoid arthritis in mice. Ann Rheum Dis. 2008 ;67:1765-72.

Delavallée L, Assier E, Semerano L, Bessis N, Boissier MC. Emerging applications of anticytokine vaccines. Expert Rev Vaccines. 2008;7:1507-17.

Delavallée L, Assier E, Denys A, Falgarone G, Zagury JF, Muller S, Bessis N, Boissier MC Vaccination with cytokines in autoimmune diseases. Ann Med. 2008;40:343-51.

Delavallée L, Le Buanec H, Bessis N, Assier E, Denys A, Bizzini B, Zagury D, Boissier MC. Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNFalpha. Ann Rheum Dis. 2008;67:1332-8.

Boissier M-C, Lemeiter D., Valvason C Clavel G, Laroche L. , Begue T., and Bessis N. Synoviocytes infection by AAV is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype. Hum Gene Ther, 2007 , 18 : 525-35.

Clavel C, Bessis N, Fardellone P, Othmane M, Menard JF, Pouplin S, Boumier P, Vittecoq O, Le Loêt X, Boissier MC. Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction. Clin Immunol,2007, 124: 158-64.

Le Buanec H*, Delavallée L*, Bessis N,  Paturance S, Bizzini B, Gallo R,  Zagury D, Boissier MC. TNFα kinoid vaccination-induced neutralizing antibodies to TNFα protects mice from autologous TNFα driven chronic and acute inflammation (* same ctd). Proc Natl Acad Sci, 2006,103:19442-7

Bertin-Maghit SM, Capini CJ , Bessis N, Chomilier J, Muller S, Abbas A, Regulier EG, Rappaport J, Therwath A, Zagury JF*, Boissier MC*. Improvement of collagen-induced arthritis by active immunization against murine IL-1 peptides designed by molecular modelling. Vaccine 2005, 23:4228-35 (* same cont.)

Maravic M, Bergé C, Daurès JP, Boissier MC Practices for Managing a Flare of Long-Standing Rheumatoid Arthritis: Survey among French Rheumatologists, Clin Exp Immunol, 2005,23:36-42

Saidenberg-Kermanac’h N, Corrado A, Lemeiter D, de Vernejoul MC, Boissier MC, Cohen-Solal M. TNF-a antibodies and osteoprotegerin decrease systemic bonne loss-associated with inflammation through distinct mechanisms in collagen-induced arthritis. Bone, 2004, 35:1200-7

Bessis N*, Bloquel N*, Boissier MC, Scherman D, Bigey P. Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-alpha soluble receptor I variants. Hum Gene Ther 2004 ; 15 : 189-201

Cottard V, Valvasson C, Falgarone G, Lutomski D, Boissier MC, Bessis N Effect of Synovial Fluid on Adeno-Associated Virus-Mediated Gene Transfer to Chondrocytes J Clin Immunol, 2004, 24 : 162-9

Garcia de la Pena-Lefebvre P, Chanseaud Y, Tamby MC, Reinbolt J, Batteux F, Allanore Y, Kahan A, Meyer O, Benveniste O, Boyer O, Guillevin L, Boissier MC, Mouthon L. IgG reactivity with a 100 kDa tissue and endothelial cell antigen identified as topoisomerase 1 distinguishes between limited abd diffuse systemic sclerosis patients. Clin Immunol 2004, 11:241-51

Maravic M, Bergé C, Daurès JP, Boissier MC Survey of Practices Regarding Management of Early Typical Rheumatoid Arthritis by Rheumatologists in France, Clin Exp Rheumatol, 2004, 22:319-27

Saidenberg-Kermanac’h N, Bessis N, Lemeiter D, de Vernejoul MC, Boissier MC, Cohen-Solal M. Osteoprotegerin and interleukin-4 cellular gene therapy decrease bone resorption-associated inflammation in collagen-induced arthritis. J Clin Immunol, 2004, 24 :370-8

Saidenberg-Kermanac’h N, Bessis N, Deleuze V, Blocquel C, Bureau M, Scherman D,Boissier MC. Efficacy of interleukin-10 gene electrotransfer into skelettal muscle in mice with collagen-induced arthritis, J Gene Med, 2003, 5; 164-71

Bessis N, Cottard V, Saidenberg-Kermanac’h N, Lemeiter D, Fournier C, Boissier MC. Syngeneic fibroblasts engineered to secrete interleukin-4 as vectors for antiinflammatory gene therapy in collagen-induced arthritis. J Gene Med, 2002, 4 :300-7

Saidenberg-Kermanac’h N, Bessis N, Cohen-Solal M, de Vernejoul M, Boissier MC. Osteoprotegerin and inflammation. Eur Cytokine Netw, 2002, 13 :144-53

Bessis N, Doucet C, Cottard V, Douar AM, Firat H, Jorgensen C, Mezzina M, Boissier MC Gene therapy for rheumatoid arthritis, J Gene Med, 2002 ;4 :581-91

Guedes C, Bianchi-Fior P, Cormier B, Barthelemy B, Rat AC, Boissier MC. Cardiac manifestations of rheumatoid arthritis : a case control transoesophageal echocardiography study in 30 patients. Arthritis Rheum , 2001, 45:129-35.

Guéry L, Chiocchia G, Batteux F, Boissier MC C, Fournier C. Collagen II-pulsed antigen-presenting cells engineered to secrete IL-4 down regulate collagen-induced arthritis. Gene Ther, 2001, 8 : 1855,62

Guéry L, BatteuxF, Bessis N, Bréban M, Boissier MC, Fournier C, Chiocchia G. Expression of fas ligand improves the therapeutic effect if IL-4 in collagen-induced arthritis. Eur J Immunol, 2000;30:308-15

Bessis N, Guéry L, Mantovani A, Vecchi A, Sims J, Fradelizi D, Boissier MC. The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis, Eur J Immunol,2000;30:867-75

Cottard V, Mulleman Bouillé P, Mezzina M, Boissier MC, Bessis N. Adeno-associated virus mediated delivery of IL-4 prevents collagen-induced arthritis. Gene Ther, 2000; 7: 1930-9

2. Previous papers from P Decker

Lindau D, Rönnefarth V, Erbacher A, Rammensee HG, Decker P. Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: implications for systemic lupus erythematosus. Eur J Immunol, 2011, 41:669-81.

Bürk K, Wick M, Roth G, Decker P, Voltz, R. Antineuronal antibodies in sporadic late-onset cerebellar ataxia. J Neurol, 2010, 257:59-62.

Bürk K, Farecki ML, Lamprecht G, Roth G, Decker P, Weller M, Rammensee HG, Oertel WHO. Neurological symptoms in patients with biopsy proven celiac disease. Mov Disord, 2009, 24:2358-62.

Lindau D, Decker P. Neutrophils, dendritic cells and chromatin-mediated pathogenesis in systemic lupus erythematosus. Autoimmunity, 2009, 42:254-6.

Erbacher A, Decker P. Chromatin modifications, oxidative stress and nucleosome autoantibodies. In: The epigenetics of autoimmune diseases, 2009, 119-34. Editor, Moncef Zouali; Publisher, Wiley Inc., New York.

Kloss M*, Decker P*, Baltz K, Baessler T, Jung G, Rammensee HG, Steinle A, Krusch M, Salih H. Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA. J Immunol, 2008, 181: 6711-19. *The first two authors contributed equally to this work.

Hervé R, Schmitz T, Evain-Brion D, Cabrol D, Leroy MJ, Méhats C. The PDE4 inhibitor rolipram prevents NF-kappaB binding activity and proinflammatory cytokine release in human chorionic cells. J Immunol. 2008 Aug 1;181(3):2196-202.

Erbacher A, Rönnefarth V, Decker P. Circulating nucleosomes due to a defective clearance of dying cells: consequences in systemic lupus erythematosus. Autoimmunity, 2007, 40:311-14.

Dali H, Busnel O, Hoebeke J, Bi L, Decker P, Briand JP, Baudy-Floc’h M, Muller S. Heteroclitic properties of mixed a- and aza-b3-peptides mimicking a supradominant CD4 T cell epitope presented by nucleosome. Mol Immunol, 2007, 44:3024-36.

Rönnefarth V, Erbacher A, Lamkemeyer T, Madlung J, Nordheim A, Rammensee HG, Decker P. TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus. J Immunol, 2006, 177:7740-9.

Decker P, Kötter I, Klein R, Berner B, Rammensee HG. Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus. Rheumatology, 2006, 45:1087-95.

Decker P, Singh-Jasuja H, Haager S, Kötter I, Rammensee HG. Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation. J Immunol, 2005, 174:3326-34.

Dengjel J*, Decker P*, Schoor O, Altenberend F, Weinschenk T, Rammensee HG, Stevanovic S. Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectromotry. Eur J Immunol, 2004, 34:3644-51. *The first two authors contributed equally to this work.

Decker P, Wolburg H, Rammensee HG. Nucleosomes induce lymphocyte necrosis. Eur J Immunol, 2003, 33:1978-87.

Williams RC, Malone CC, Meyers C, Decker P, Muller S. Detection of nucleosome particles in the sera of patients with SLE using monoclonal antibody 4H7. J Rheumatol, 2001, 28:81-94.

Decker P, Isenberg DA, Muller S. Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis. J Biol Chem, 2000, 275:9043-6.

Monestier M, Decker P, Briand JP, Gabriel JL, Muller S. Molecular and structural properties of three autoimmune IgG monoclonal antibodies to histone H2B. J Biol Chem, 2000, 275:13558-63.

Decker P, Le Moal A, Briand JP, Muller S. Identification of a minimal T cell epitope recognised by anti-nucleosome Th cells in the C-terminal region of histone H4. J Immunol, 2000, 165:654-62.

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