JEROME BITON

 • The new histological classification of lung primary adenocarcinoma subtype is a reliable prognostic marker and it identifies tumours with different mutation status: the experience of a French cohort. Mansuet-Lupo A, Bobbio A, Blons H, Becht E, Ouakrim H, Didelot A, Charpentier MC, Bain S, Marmey B, Bonjour P, Biton J, Cremer I, Dieu-Nosjean MC, Sautès-Fridman C, Régnard JF, Laurent-Puig P, Alifano M, Damotte D. Chest. 2014 Sep;146(3):633-43.
• Systemic inflammation, nutritional status and tumor immune microenvironment determine outcome of resected non-small cell lung cancer. Alifano M, Mansuet-Lupo A, Lococo F, Roche N, Bobbio A, Canny A, Schussler O, Dermine H, Régnard JF, Burroni B, Goc J, Biton J, Ouakrim H, Dieu-Nosjean MC, Cremer I and Damotte D. PLOS ONE. 2014 Sep 19;9(9):e106914.
• Calreticulin expression by non-small-cell lung cancer correlates with signs of immunosurveillance and favorable prognosis. J. Fucikova, E. Becht, K. Iribarren, J. Goc, R. Remark, D. Damotte, M. Alifano, P. Devi, J. Biton, C. Germain, W. H. Fridman, M-C. Dieu-Nosjean, G. Kroemer, C. Sautès-Fridman, I. Cremer. Cancer research. 2016 Apr 1;76(7):1746-56.
• Intra-tumoral immune cell densities are associated with lung adenocarcinoma gene alterations. Mansuet-Lupo A, Alifano M, Pécuchet N, Biton J, Becht E, Goc J, Germain C, Ouakrim H, Régnard JF, Cremer I, Laurent-Puig P, Dieu-Nosjean MC, Blons H, Damotte D. American Journal of Respiratory and Critical Care Medicine. 2016.
• Immune contexture and histological response after neoadjuvant chemotherapy predict clinical outcome of lung cancer patients. R. Remark, A. Lupo, M. Alifano, J. Biton, H. Ouakrim, A. Stefani, I. Cremer, J. Goc, J-F Régnard, M-C Dieu-Nosjean and D. Damotte. Oncoimmunology. 2016 Dec 8; 5 (12).
• Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment. E. Peranzoni, J. Lemoine, L. Vimeux, V. Feuillet, S. Barrin, C. Kantari, N. Bercovici, M. Guerin, J. Biton, H. Ouakrim, F. Regnier, A. Lupo, M. Alifano, D. Damotte, E.Donnadieu. Proceedings of the National Academy of Sciences. 2018 Apr 24;115(17):E4041-E4050.
• Impaired tumor-infiltrating T cells in patients with COPD impacts lung cancer response to PD-1 blockade. J. Biton, H. Ouakrim, A. Dechartres, M. Alifano, A. Mansuet-Lupo, H. Si, R. Halpin, T. Creasy, C. Bantsimba-Malanda, J. Arrondeau, F. Goldwasser, P. Boudou-Rouquette, L. Fournel, N. Roche, P-R. Burgel, J. Goc, P. Devi-Marulkar, C. Germain, M-C. Dieu-Nosjean, I. Cremer, R. Herbst, D. Damotte. American Journal of Respiratory and Critical Care Medicine. 2018 Oct 1;198(7):928-940.
• TP53, STK11 and EGFR Mutations Predict Tumor Immune Profile and the Response to anti-PD-1 in Lung Adenocarcinoma. J. Biton, A. Mansuet-Lupo, N. Pécuchet, M. Alifano, H. Ouakrim, J. Arrondeau, P. Boudou-Rouquette, F. Goldwasser, K. Leroy, J. Goc, C. Germain, P. Laurent-Puig, M-C. Dieu-Nosjean, I. Cremer, R. Herbst, H. Blons, D. Damotte. Clinical Cancer Research. 2018 Nov 15;24(22):5710-5723.
• Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcome. V. M. Braud, J. Biton, E. Becht, S. Knockaert, A. Mansuet-Lupo, E. Cosson, D. Damotte, M. Alifano, P. Validire, F. Anjuère, I. Cremer, N. Girard, D. Gossot, A.Seguin-Givelet, M-C Dieu-Nosjean & C. Germain. Oncoimmunology. 2018 Dec 8; 5 (12).
• Proposal for a combined histo-molecular algorithm to distinguish multiple primary adenocarcinomas from intrapulmonary metastasis in patients with multiple lung tumors. A. Mansuet-Lupo, M. Barritault, M. Alifano, A Janet-Vendroux, M. Zarmaev, J. Biton, Y. Velut, C. Le Hay, I. Cremer2, J-F Régnard, L. Fournel, B. Rance, M. Wislez, P. Laurent-Puig, R. Herbst, D. Damotte, H. Blons. Journal of Thoracic Oncology. 2019 May;14(5):844-856.
• The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort. D. Damotte, S.Warren, J. Arrondeau, P. Boudou-Rouquette, A. Lupo, J. Biton, H. Ouakrim, M. Alifano, C. Gervais, A, Bellesoeur, N. Kramkimel, C. Tlemsani, B. Burroni, A. Duche, F. Letourneur, H. Si, R. Halpin, T. Creasy, R. Herbst, X. Ren, P. Morel, A. Cesano, F. Goldwasser, K. Leroy. Journal of Translational Medicine. 2019 Nov 4;17(1):357.
• Tertiary lymphoid structure-B cells narrow regulatory T cells impact in lung cancer patients. C. Germain, P. Devi-Marulkar, S. Knockaert, J. Biton, H. Kaplon, L. Letaïef, J. Goc, A Seguin-Givelet, D. Gossot, N. Girard, P. Validire, M. Lefevre, D. Damotte, M. Alifano, F. Lemoine, K. Steele, J-L. Teillaud, S. A. Hammond and MC. Dieu-Nosjean. Frontiers in Immunology. 2021 Mar 8;12:626776.
• SMARCA4-deficient lung carcinoma is an aggressive tumor highly infiltrated by FOXP3+ cells and neutrophils. Y. Velut, E. Decroix, H. Blons, M. Alifano, K. Leroy, F. Petitprez, A. Boni, S. Garinet, J. Biton, I. Cremer, M. Wislez, P. Boudou-Rouquette, J. Arrondeau, F. Goldwasser, L. Fournel, D. Damotte, A. Mansuet-Lupo. Lung cancer. 2022, 169, 13-21. 

ELODIE RIVIERE

• Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjögren’s syndrome. E Rivière, J Pascaud, A Virone et al, Arthritis Rheumatol. 2021 ; 3(4):631-640
• Salivary gland epithelial cells from patients with Sjögren's syndrome induce B-lymphocyte survival and activation. E Rivière, J Pascaud, N Tchitchek, et al., , Ann Rheum Dis. 2020 ; 79:1468-1477
• Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis. E Rivière¹, J Sellam¹, A Courties, et al., , Arthritis Res Ther. 2016 ; 18(1):294. ¹equal contributors
• Clinicopathological features of multiple mononeuropathy associated with systemic lupus erythematosus: a multicenter study. E Rivière, F Cohen Aubart, T Maisonobe, et al., Journal of Neurology, 2017;264(6):1218-1226
• Restoration of default blood monocyte-derived macrophage polarization with adalimumab but not etanercept in rheumatoid arthritis. A Paoletti, B Ly, S Bitoun, G Nocturne, E Rivière, et al., Frontiers in Immunology, 2022 ; 23;13:832117
• Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome. Dupré A, Pascaud J, Rivière E, et al., RMD Open. 2021; 7(1):e001442
• Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors. A Paoletti, J Rohmer, B Ly, J Pascaud, E Rivière, R Seror, B Le Goff, G Nocturne, X Mariette, J Immunol, 2019 ; 1;203(7):1766-1775
• Role of the IL-12/IL-35 balance in patients with Sjögren syndrome. Fogel O, Rivière E, Seror R, et al.,. J Allergy Clin Immunol. 2018 ; 142(1):258-268.e5

LEA PAOLINI

• J-F Augusto^†, C Beauvillain^†, C Poli, L Paolini, I Tournier, P Pignon, S Blanchard, L Preisser, R Soleti, C Delépine, M Monnier, I Douchet, P Asfar, F Beloncle, O Guisset, R Prével, A Mercat, E Vinatier, J Goret, J-F Subra, D Couez, M R W, P Blanco, P Jeannin, Y Delneste, Clusterin Neutralizes the Inflammatory and Cytotoxic Properties of Extracellular Histones, Am J Respir Crit Care Med. 2023 May 4, PMID: 37141109
• T Tran , J-R Lavillegrand, C Lereverend, B Esposito, L Cartier, M Montabord , J Tran-Rajau, M Diedisheim, N Gruel, K Ouguerram, L Paolini, O Lenoir, E Pinteaux, E Brabencova, C Tanchot, P Urquia, J Lehmann-Che, R Le Naour, Y Merrouche, C Stockmann, Z Mallat, A Tedgui, H Ait-Oufella, E Tartour , S Potteaux , Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells, Nature Communication. 2022;13(1):5399. PMID: 36104342
• L Paolini^†, C Adam^†, N Gueguen^†, G Mabilleau, L Preisser, S Blanchard, P Pignon, F Manero, M Le Mao, A Morel, P Renier, C Beauvillain, Y Delneste^‡, V Procaccio^‡, P Jeannin^‡ Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming Nature Communication 12, 7115 (2021) PMID: 34880237 
• S Karaki ^†, C Blanc^†, T Tran^†, I Galy-Fauroux, A Mougel, E Dransart, M Anson, C Tanchot , L Paolini, N Gruel, L Gibault, F Lepimpec-Barhes, E Fabre, N Benhamouda, C Badoual, D Damotte, E Donnadieu, S Kobold, F Mami-Chouaib, R Golub, L Johannes, E Tartour, CXCR6 deficiency impairs cancer vaccine efficacy and CD8 + resident memory T-cell recruitment in head and neck and lung tumors, J journal for Immunotherapy of Cancer. 2021 Mar;9(3):e001948 PMID: 33692218
• L Paolini^†, C Adam^†, C Beauvillain, L Preisser, S Blanchard, P Pignon, V Seegers, L-M Chevalier, M Campone, R Wernert, V Verriele, P Raro, N Ifrah, V Lavoue, P Descamps, Morel, V Catros, G Tcherkez, G Lenaers, C Bocca, J Kouassi Nzoughet, V Procaccio, Y Delneste and P Jeannin. Lactic acidosis together with GM-CSF and M-CSF induces human macrophages toward an inflammatory pro-tumor phenotype. Cancer Immunology Research. 2020 Jan 10. pii: canimm.0749.201. PMID 31924656
• L Paolini, C Poli, S Blanchard, T Urban, A Croué, M-Ch Rousselet, S Le Roux, N Labarrière, P Jeannin, J Hureaux. Thoracic and cutaneous sarcoid-like reaction associated with anti-PD-1 therapy: longitudinal monitoring of PD-1 and PD-L1 expression after stopping treatment, Journal for Immunotherapy of Cancer. 2018 Jun 13;6(1):52 , PMID 29898781
• C Rabu, L Rangan, L Florenceau, A Fortun, M Charpentier, E Dupré, L Paolini, C Beauvillain, E Dupel, J-B Latouche, O Adotevi, N Labarrière & F Lang. Cancer vaccines: designing artificial synthetic long peptides to improve presentation of class I and class II T cell epitopes by dendritic cells. 2019 Jan 17;8(4):e1560919. , PMID: 30906653

Revues

• L Paolini^†, M Monnier^†, E Vinatier, A Mantovani, Y Delneste and P Jeannin et al, Antitumor strategies targeting macrophages: the importance of considering the differences in differentiation/polarization processes between human and mouse macrophages, Journal for ImmunoTherapy of Cancer 2022;10:e005560. PMID:36270732
• L Paolini, A Saldmann, E Tartour, Lymphocytes T-CD8 et immunothérapie anti-tumorale: rôle et ciblage thérapeutique. Bulletin de l'Académie Nationale de Médecine, Volume 205, Issue 4, 2021, Pages 354-363, DOI : 10.1016/j.banm.2021.01.018
• E De Guillebon, A Dardenne, A Saldmann, S Séguier, T Tran, L Paolini, C Lebbe, E Tartour, Beyond the Concept of Cold and Hot Tumors for the Development of Novel Predictive Biomarkers and the Rational Design of Immunotherapy Combination, Internation Journal of Cancer, 2020 Jan 30. doi: 10.1002/ijc.32889 , PMID: 31997345
• P Jeannin, L Paolini, C Adam, Y Delneste. The roles of CSFs on the functional polarization of tumor- associated macrophages. FEBS J. 2018 Feb;285(4):680-699 , PMID 29171156

PATRICE DECKER

• Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: implications for systemic lupus erythematosus. Lindau D, Rönnefarth V, Erbacher A, Rammensee HG, Decker P. Eur J Immunol, 2011, 41:669-81.
• Antineuronal antibodies in sporadic late-onset cerebellar ataxia. Bürk K, Wick M, Roth G, Decker P, Voltz, R.  J Neurol, 2010, 257:59-62.
• Neurological symptoms in patients with biopsy proven celiac disease. Bürk K, Farecki ML, Lamprecht G, Roth G, Decker P, Weller M, Rammensee HG, Oertel WHO. Mov Disord, 2009, 24:2358-62.
• Neutrophils, dendritic cells and chromatin-mediated pathogenesis in systemic lupus erythematosus. Lindau D, Decker P.  Autoimmunity, 2009, 42:254-6.
• Chromatin modifications, oxidative stress and nucleosome autoantibodies. In: The epigenetics of autoimmune diseases. Erbacher A, Decker P.  2009, 119-34. Editor, Moncef Zouali; Publisher, Wiley Inc., New York.
• Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA. Kloss M*, Decker P*, Baltz K, Baessler T, Jung G, Rammensee HG, Steinle A, Krusch M, Salih H.  J Immunol, 2008, 181: 6711-19. *The first two authors contributed equally to this work.
• The PDE4 inhibitor rolipram prevents NF-kappaB binding activity and proinflammatory cytokine release in human chorionic cells. Hervé R, Schmitz T, Evain-Brion D, Cabrol D, Leroy MJ, Méhats C. J Immunol. 2008 Aug 1;181(3):2196-202.
• Circulating nucleosomes due to a defective clearance of dying cells: consequences in systemic lupus erythematosus. Erbacher A, Rönnefarth V, Decker P.  Autoimmunity, 2007, 40:311-14.
• Heteroclitic properties of mixed a- and aza-b3-peptides mimicking a supradominant CD4 T cell epitope presented by nucleosome. Dali H, Busnel O, Hoebeke J, Bi L, Decker P, Briand JP, Baudy-Floc’h M, Muller S.  Mol Immunol, 2007, 44:3024-36.
• TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus. Rönnefarth V, Erbacher A, Lamkemeyer T, Madlung J, Nordheim A, Rammensee HG, Decker P. J Immunol, 2006, 177:7740-9.
• Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus. Decker P, Kötter I, Klein R, Berner B, Rammensee HG.  Rheumatology, 2006, 45:1087-95.
• Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation. Decker P, Singh-Jasuja H, Haager S, Kötter I, Rammensee HG.  J Immunol, 2005, 174:3326-34.
• Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectromotry. Dengjel J*, Decker P*, Schoor O, Altenberend F, Weinschenk T, Rammensee HG, Stevanovic S. Eur J Immunol, 2004, 34:3644-51. *The first two authors contributed equally to this work.
• Nucleosomes induce lymphocyte necrosis. Decker P, Wolburg H, Rammensee HG.  Eur J Immunol, 2003, 33:1978-87.
• Detection of nucleosome particles in the sera of patients with SLE using monoclonal antibody 4H7. Williams RC, Malone CC, Meyers C, Decker P, Muller S.  J Rheumatol, 2001, 28:81-94.
• Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis. Decker P, Isenberg DA, Muller S.  J Biol Chem, 2000, 275:9043-6.
• Molecular and structural properties of three autoimmune IgG monoclonal antibodies to histone H2B. Monestier M, Decker P, Briand JP, Gabriel JL, Muller S.  J Biol Chem, 2000, 275:13558-63.
• Identification of a minimal T cell epitope recognised by anti-nucleosome Th cells in the C-terminal region of histone H4. Decker P, Le Moal A, Briand JP, Muller S.  J Immunol, 2000, 165:654-62.